ST. HELIER, Jersey--(BUSINESS WIRE)--Novocure™ (NASDAQ: NVCR) announced today that Novocure’s inovitro™ laboratory research system will be used to study Tumor Treating Fields (TTFields) therapy at The University of Texas MD Anderson Cancer Center. MD Anderson will study the effect of TTFields therapy on glioma stem-like cells to determine factors influencing sensitivity and resistance to TTFields alone and in combination with radiation therapy.
The inovitro system was developed by Novocure in 2013 and is a plug-and-play lab research tool. The system allows investigators to efficiently study the effects of different field parameters and TTFields’ synergies with various drug and radiation combinations. It consists of eight TTFields generators controlled by proprietary software with ultra-high dielectric constant ceramic petri dishes. Using inovitro, researchers can customize intensity and frequency to easily study the effect of TTFields in various cancer cells while optimizing treatment parameters and treatment combinations.
“We are honored that MD Anderson Cancer Center is collaborating with Novocure to research TTFields therapy,” said Dr. Moshe Giladi, Head of Preclinical Research at Novocure. “Such collaborations with the medical community demonstrate a growing interest in our therapy and contribute to a deeper understanding of the mechanisms of action underlying TTFields.”
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MD Anderson Cancer Center is the 10th academic research center to date to study TTFields using the inovitro system.
“MD Anderson’s collection of glioma stem-like cells, which have undergone comprehensive genomic and proteomic analyses, could play an important role in the characterization of responses to TTFields combinations in cells with various properties,” said Dr. Eilon Kirson, Novocure’s Chief Science Officer and Head of Research and Development. “Such findings may even, in the future, allow for the discovery of patient-specific biomarkers for response or resistance to TTFields combinations with various therapies.”
About Tumor Treating Fields Therapy
Tumor Treating Fields (TTFields) therapy is delivered by a portable, non-invasive medical device designed for continuous use by patients. In vitro and in vivo studies have shown that TTFields therapy slows and reverses tumor growth by inhibiting mitosis, the process by which cells divide and replicate. TTFields therapy creates low intensity, alternating electric fields within a tumor that exert physical forces on electrically charged cellular components, preventing the normal mitotic process and causing cancer cell death.
