The AHRQ report found that IMRT leads to fewer cases of xerostomia than traditional two-dimensional or three-dimensional radiation therapies, probably because IMRT delivers radiation more precisely. It also found that IMRT improves some aspects of quality of life related to xerostomia. However, the evidence did not conclude that IMRT is better than traditional therapies at reducing the tumors themselves.
In this comparative effectiveness review, researchers also examined the evidence regarding proton beam radiation therapy, a technology that some clinicians believe targets radiation even more precisely than IMRT. However, researchers did not find enough evidence to draw any conclusions regarding the benefits or potential side effects of proton beam therapy, which is more commonly used to treat prostate cancer and pediatric tumors. In an AHRQ Technical Brief published last fall, researchers found limited evidence regarding whether proton beam radiation therapy is safer or more effective than other types of radiation to treat cancer.

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Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer is the newest research review from the AHRQ's Effective Health Care Program. The Effective Health Care Program represents the leading federal effort to compare alternative treatments for health conditions and make the findings public, to help doctors, nurses, pharmacists and others work together with patients to choose the most effective treatments.
In conjunction with the new report, AHRQ will soon publish in plain-language summary guides about radiation therapy for head and neck cancer treatment for patients, clinicians and policymakers. Summary guides on numerous clinical topics such as medicines to reduce the risk of breast cancer and choosing pain medicine for osteoarthritis, as well as other information and background on the Effective Health Care Program, can be found at www.effectivehealthcare.ahrq.gov.
SOURCE Agency for Healthcare Research & Quality
http://www.effectivehealthcare.ahrq.gov/
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