Leesburg, VA, November 13, 2020—According to an article in ARRS’ American Journal of Roentgenology (AJR), positive conclusions—but not titles—were associated with a shorter time from study completion to publication, which may contribute to an overrepresentation of positive results in the imaging diagnostic test accuracy (DTA) literature.
“We included primary imaging DTA studies from systematic reviews published in 2015,” explained first author Lee M. Treanor of Ottawa Hospital Civic Campus. Extracting both the conclusion and the title of each study, positivity was independently classified in duplicate. The time from study completion to publication was also extracted and calculated. Hazard ratios were estimated using a multivariable Cox regression model to determine the strength of the associations, adjusting for potentially confounding variables.
Based up the researchers’ MEDLINE search, 781 studies appeared eligible for inclusion. Excluding seven studies (three for not having an abstract, three for not being a primary DTA study, and one because it was a duplicate) yielded a total of 774 imaging DTA studies; however, time from study completion to publication could only be calculated for 516 studies.
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The median time from study completion to publication was 18 months (interquartile range [IQR], 13–26 months) for the 413 studies with positive conclusions, compared with 23 months (IQR, 16–33 months) for the 63 studies with neutral conclusions and 25 months (IQR, 15–38 months) for the 40 studies with negative conclusions.
For studies with positive titles, the median time from study completion to publication was 18 months (IQR, 11–26 months), compared with 19 months (IQR, 13–28 months) for studies with neutral titles and 30 months (IQR, 24–34 months) for studies with negative titles.
Time Between Study Phases Based on Classification of Degree of Positivity of Conclusion and Title
Note—IQR = interquartile range, NA = not applicable.
“Of all included studies,” Treanor et al. tallied, “39 (5%) had positive titles, 731 (94%) had neutral titles, and 4 (< 1%) had negative titles,” concluding that positive titles were not significantly associated with a shorter time to study publication (hazard ratio, 1.12; 95% CI, 0.75–1.69).
Because an inflated perception of test performance could adversely influence clinical decision making and patient care, the authors of this AJR article suggested bias reduction strategies “should undergo trials by both journal editors and researchers in the imaging DTA community.”
Founded in 1900, the American Roentgen Ray Society (ARRS) is the first and oldest radiological society in North America, dedicated to the advancement of medicine through the profession of radiology and its allied sciences. An international forum for progress in medical imaging since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with an annual scientific meeting, monthly publication of the peer-reviewed American Journal of Roentgenology (AJR), quarterly issues of InPractice magazine, AJR Live Webinars and Podcasts, topical symposia, print and online educational materials, as well as awarding scholarships via The Roentgen Fund®.